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The Hofmann-Martius rearrangement in organic chemistry is a rearrangement reaction converting an N-alkylated aniline to the corresponding ortho and / or para aryl-alkylated aniline. The reaction requires heat and the catalyst is an acid like hydrochloric acid  
Additional recommended knowledge
When the catalyst is a metal halide the reaction is also called the Reilly-Hickinbottom rearrangement .
The reaction is also known to work for aryl ethers and two conceptually related reactions are the Fries rearrangement and the Fischer-Hepp rearrangement. Its reaction mechanism centers around dissociation of the reactant with the positively charged organic residue R attacking the aniline ring in a Friedel-Crafts alkylation.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Hofmann-Martius_rearrangement". A list of authors is available in Wikipedia.|