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Systematic (IUPAC) name
(8,8-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenyl-acetate bromide
CAS number 80-49-9
ATC code A02BX03 S01FA05
PubChem 6646
DrugBank APRD01017
Chemical data
Formula C17H24BrNO3 
Mol. mass 370.28 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Homatropine (Equipin®, Isopto Homatropine®) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil.

Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromide salt.

Drugs like hydrocodone are mixed with small amounts of an anticholinergic such as homatropine methylbromide to discourage abuse.

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administation.

Side effects


  • Untreated glaucoma
  • Myasthenia gravis
  • Severe heart failure
  • Thyrotoxicosis

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Homatropine". A list of authors is available in Wikipedia.
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