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Impalefection is a method of gene delivery using nanomaterials, such as carbon nanofibers, nanotubes, nanowires Ref.1. Needle-like nanostructures are synthesized perpendicular to the surface of a substrate. Plasmid DNA containing the gene, intended for intracellular delivery, is attached to the nanostructure surface. A chip with arrays of these needles is then pressed against cells or tissue. Cells that are impaled by nanostructures can express the delivered gene(s).
Additional recommended knowledge
Similar to transfection, the term is derived from two words - impalement and infection.
1. Tracking gene expression after DNA delivery using spatially indexed nanofiber arrays McKnight, T.E., A.V. Melechko, D.K. Hensley, D.G.J. Mann, G.D. Griffin, and M.L. Simpson, . Nano Letters, 2004. 4(7): p. 1213-1219
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Impalefection". A list of authors is available in Wikipedia.|