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Isatin or 1H-indole-2,3-dione is an indole derivative. The compound was first obtained by Erdman and Laurent in 1841 as a product from the oxidation of Indigo dye by nitric acid and chromic acids. The compound is found in many plants and Schiff bases of Isatin are investigated for their pharmaceutical properties .
Additional recommended knowledge
It was observed that isatin forms a blue dye if it s mixed with sulfuric acid and crude benzene. The formation of the blue indophenin was long believed to be areaction with benzene. Victor Meyer was able to isolate the substance resposible for this reaction from benzene. This new heterocyclic compound was thiophene. 
Isatins can be made from the corresponding indole in good yield by a mix of InCl3 and IBX in a acetonitrile-water solution at 80 °C.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Isatin". A list of authors is available in Wikipedia.|