KASH domain

KASH (Klarsicht, ANC-1, Syne Homology) domains are conserved C-terminal protein regions less than ~30 amino acids. KASH domains always follow a transmembrane domain. Most proteins containing KASH domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that KASH domains interact with proteins containing SUN domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope and transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton. Some proteins that contain KASH domains are:

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Caenorhabditis elegans

• UNC-83
• ANC-1
• ZYG-12

Mammals

• Nesprins-1, 2, and 3 (also called Synes, Mynes, Nuance, Enaptin)

Drosophila melanogaster

• Klarsicht

References:

Bioessays. 2005 Nov;27(11):1136-46.