SUN domain

SUN (Sad1p, UNC-84) domains are conserved C-terminal protein regions a few hundred amino acids long. SUN domains are usually found following a transmembrane domain and a less conserved region of amino acids. Most proteins containing SUN domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that SUN domains interact directly with KASH domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope and transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton. Some proteins that contain SUN domains are:

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Caenorhabditis elegans

• SUN-1/matefin
• UNC-84

Mammals

• SUN1, 2, and 3
• SPAG4

Schizosaccharomyces pombe

• Sad1p

References:

Nat Rev Mol Cell Biol. 2006 Oct;7(10):782-8.