Kornblum oxidation

The Kornblum oxidation is a chemical reaction of a primary halide with dimethyl sulfoxide (DMSO) to form an aldehyde.^{[1]KornblumPrimary2Dave1986} Like all DMSO-based oxidations, the Kornblum oxidation creates an alkoxysulphonium ion, which, in the presence of a base, such as triethylamine (Et₃N), will eliminate to form the desired aldehyde.

References

1. ^  Kornblum, N.; Jones, W. J.; Anderson, G. J. J. Am. Chem. Soc. 1959, 81, 4113.
2. ^  Kornblum, N.; Jones, W. J.; Anderson, G. J.; Powers, J. W.; Larson, H. O.; Levand, O.; Wraver, W. M. J. Am. Chem. Soc. 1957, 79, 6562.
3. ^  Dave, P.; Byun, H. S.; Engel, R. Synth. Commun. 1986, 16, 1343.

See also

• Ganem oxidation
• Swern oxidation