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Kornblum oxidation

The Kornblum oxidation is a chemical reaction of a primary halide with dimethyl sulfoxide (DMSO) to form an aldehyde.[1]KornblumPrimary2Dave1986 Like all DMSO-based oxidations, the Kornblum oxidation creates an alkoxysulphonium ion, which, in the presence of a base, such as triethylamine (Et3N), will eliminate to form the desired aldehyde.


  1. ^  Kornblum, N.; Jones, W. J.; Anderson, G. J. J. Am. Chem. Soc. 1959, 81, 4113.
  2. ^  Kornblum, N.; Jones, W. J.; Anderson, G. J.; Powers, J. W.; Larson, H. O.; Levand, O.; Wraver, W. M. J. Am. Chem. Soc. 1957, 79, 6562.
  3. ^  Dave, P.; Byun, H. S.; Engel, R. Synth. Commun. 1986, 16, 1343.

See also

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Kornblum_oxidation". A list of authors is available in Wikipedia.
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