My watch list  


IUPAC name L-Arginine, L-tyrosyl-
Other names kiotorphin
CAS number 70904-56-2
Molecular formula C15H23N5O4
Molar mass 337.374 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain. It was first isolated from bovine brain by Japanese scientists in 1979[1]. Kyotorphin was named for the site of its discovery, Kyoto, Japan and because of its morphine- (or endorphin-) like analgesic activity. Kyotorphin has an analgesic effect, but it does not interact with the opioid receptors. Instead, it acts by releasing an Met-enkephalin and stabilizing it from degradation. It may also possess properties of neuromediator/neuromodulator. It has been shown that kyotorphin is present in the human cerebrospinal fluid and that it is lower in patients with persistent pain[2].


  1. ^ Takagi H, Shiomi H, Ueda and Amano H (1979) A novel analgesic dipeptide from bovine brain is a possible met-enkephalin releaser. Nature (Lond) 282: 410-412.
  2. ^ K, Kaya K, Hazato T, Ueda H, Satoh M, Takagi H. (1991) Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain Masui. Nov;40(11):1686-90.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Kyotorphin". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE