To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
If a drug takes a long time to reach therapeutic levels, then a higher dose (the loading dose) may be given initially before dropping down to a lower maintenance dose.
Additional recommended knowledge
Drugs which may be started with an initial loading dose include digoxin, teicoplanin, voriconazole and procainamide. Phenytoin for acute status epilepticus should also be given with an initial loading dose, co-administered with a benzodiazepine, to immediately stabilize neuronal membranes and electrical activity during a seizure.
Calculating loading dose
Three variables are used to calculate loading dose:
Loading dose = Cp * Vd / F
For an IV, bioavailability = 1, since the drug is directly introducted to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, etc.), requiring a larger loading dose.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Loading_dose". A list of authors is available in Wikipedia.|