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Melanin concentrating hormone

pro-melanin-concentrating hormone
Symbol PMCH
Entrez 5367
HUGO 9109
OMIM 176795
RefSeq NM_002674
UniProt P20382
Other data
Locus Chr. 12 q23.2

Melanin-concentrating hormone (MCH) is a cyclic orexinogenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation.

In mammals it is involved in the regulation of feeding behavior and energy balance. MCH expressing neurons are located within the lateral hypothalamus and zona incerta. Despite this restricted distribution MCH neurons project widely throughout the brain. MCH knockout rats are hypophagic (eat less) and are lean. When administered centrally it increases food intake and weight gain.

See also

Melanin-concentrating hormone receptor

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Melanin_concentrating_hormone". A list of authors is available in Wikipedia.
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