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Molecular tweezers



    Molecular tweezers, sometimes termed molecular clips, are noncyclic compounds with open cavities capable of binding guests.[3] The open cavity of the molecular tweezers binds guests using non-covalent bonding including hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, π-π interactions, and/or electrostatic effects. They are analogous to macrocyclic molecular receptors except the two arms that bind the guest molecule are only connected at one end.

Additional recommended knowledge

Examples

An example of molecular tweezers was reported by Lehn and coworkers is capable of binding aromatic guests.[1] The molecular tweezers are composed of two anthracene arms held at a distance that allows aromatic guests to gain π-π interactions from both.

An example of molecular tweezers for fullerenes called a buckycatcher has been reported.[2] The molecular tweezer is composed of two concaved corannulene pincers that complement the the surface of the convex fullerene guest. An association constant of 8600 M-1 between the host buckycatcher and a C60 fullerene was using 1H NMR spectroscopy.

References

  1. ^ a b A. Petitjean, R. G. Khoury, N. Kyritsakas and J. M. Lehn (2004). "Dynamic Devices. Shape Switching and Substrate Binding in Ion-Controlled Nanomechanical Molecular Tweezers". J. Am. Chem. Soc. 126 (21): 6637-6647. doi:10.1021/ja031915r.
  2. ^ a b A. Sygula, F. R. Fronczek, R. Sygula, P. W. Rabideau and M. M. Olmstead (2007). "A Double Concave Hydrocarbon Buckycatcher". J. Am. Chem. Soc. 129 (13): 3842-3843. doi:10.1021/ja070616p.
  3. ^ Frank-Gerrit Klärner and Björn Kahlert (2003). "Molecular Tweezers and Clips as Synthetic Receptors. Molecular Recognition and Dynamics in Receptor-Substrate Complexes". Acc. Chem. Res. 36 (12): 919 -932. doi:10.1021/ar0200448.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Molecular_tweezers". A list of authors is available in Wikipedia.
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