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Neuraminic acid

Neuraminic acid
IUPAC name (4S,5R,6R,7S,8R)-5-amino-4,6,7,8,9-
pentahydroxy-2-oxo-nonanoic acid
CAS number 114-04-5
PubChem 513472
MeSH Neuraminic+Acids
Molecular formula C9H17N1O8
Molar mass 267.233 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Neuraminic acid (5-amino-3,5-dideoxy- D-glycero-D-galacto-non-2-ulosonic acid) is a 9-carbon monosaccharide. It may be theoretically visualized as the aldol-condensation product of pyruvic acid and D-mannosamine (2-amino-2-deoxy-mannose). Neuraminic acid does not occur naturally, but many of its derivatives are found widely distributed in animal tissues and in bacteria, especially in glycoproteins and gangliosides. The N- or O-substituted derivatives of neuraminic acid are collectively known as sialic acids, the predominant one being N-acetylneuraminic acid. The amino group bears either an acetyl or a glycolyl group. The hydroxyl substituents may vary considerably: acetyl, lactyl, methyl, sulfate and phosphate groups have been found.

The name "neuraminic acid" was introduced by German scientist E. Klenk in 1941, in reference to the brain lipids from which it was derived as a cleavage product.[1].

The symbol commonly used for neuraminic acid is Neu.

See also

References and notes

  1. ^ Klenk, E. 1941. Neuraminsäure, das Spaltprodukt eines neuen Gehirnlipoids. Zeitschr. f. Physiol. Chem. 1941; 268:50-58.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Neuraminic_acid". A list of authors is available in Wikipedia.
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