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IUPAC name 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
Abbreviations NTBC
CAS number 104206-65-7
PubChem 1153
SMILES C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]
Molecular formula C14H10F3NO5
Molar mass 329.228 g/mol
Melting point

140-142 °C

Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Nitirisinone is a chemical compound originally developed as an herbicide, but now being investigated as a treatment for certain forms of type 1 tyrosinaemia. The mechanism of action of nitrisinone involves inhibition of the enzyme 4-hydroxyphenylpyruvic acid oxidase, thus preventing the formation of maleylacetoacetic acid and fumarylacetoacetic acid, which have the potential to be converted to succinyl acetone, a toxin that damages the liver and kidneys.


  • Koelink, C. J. L.; van Hasselt, P.; van der Ploeg, A.; van den Heuvel-Eibrink, M. M.; Wijburg, F. A.; Bijleveld, C. M. A.; van Spronsen, F. J. Tyrosinemia type I treated by NTBC: How does AFP predict liver cancer? Molecular Genetics and Metabolism (2006), 89(4), 310-315.
  • McKiernan, Patrick J. Nitisinone in the treatment of hereditary tyrosinaemia type 1. Drugs (2006), 66(6), 743-750.
  • Kavana, Michael; Moran, Graham R. Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione. Biochemistry (2003), 42(34), 10238-10245.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nitrisinone". A list of authors is available in Wikipedia.
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