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Nitroimidazoles are imidazole heterocycles with a nitro group that have been used to combat anaerobic bacterial and parasitic infections. Perhaps the most common example is metronidazole (Flagyl ®). Other heterocycles such as nitrothiazoles (thiazole) are also used for this purpose. Nitroheterocycles may be reductively activated in hypoxic cells, and then undergo redox recycling or decompose to toxic products.


  • Annu. Rev. Pharmacol. Toxicol. 1989. 29:165~7
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