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Nonsense mediated decay

Nonsense mediated decay (NMD) is a cellular mechanism of mRNA surveillance to detect nonsense mutations and prevent the expression of truncated or erroneous proteins. NMD is triggered by exon-junction complexes (EJC), that have been formed during pre-RNA processing, being downstream of the nonsense codon. Normally, these EJCs are removed during the first round of translation of the mRNA, but in the case of a premature stop codon, they are still present on the mRNA. This is identified as a problem by NMD factors and the RNA is degraded, for example by the exosome complex. [1]

See also


  1. ^ Chang et al. (2007). "The nonsense-mediated decay RNA surveillance pathway". Annu Rev Biochem. 76: 51-74. PMID 17352659.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nonsense_mediated_decay". A list of authors is available in Wikipedia.
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