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In organic chemistry, an orthoester is a functional group containing three alkoxy groups attached to one carbon atom. The name can also refer to any organic compound that contains this functional group. An example of an orthoester is ethyl orthoacetate, CH3C(OCH2CH3)3. Orthoesters are used in organic synthesis as protecting groups for esters. Although orthoesters are not an ester themselves, they are called as such due to the ester function that appears when the orthoester is hydrolized. For example, trimethyl orthoformate ( CH(OCH3)3 )will be hydrolized (under acidic conditions) to methylmethanoate and methanol.
Additional recommended knowledge
Orthoesters can be prepared by the reaction of nitriles with alcohols under acid catalysis:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Orthoester". A list of authors is available in Wikipedia.|