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Additional recommended knowledge
The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in length and has an amidated C terminus. The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an alpha-helix,held close to the first helix by hydrophobic interactions. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solution. Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectively.
Human proteins containing this domain
NPY; PPY; PYY;
This article includes text from the public domain Pfam and InterPro IPR001955
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pancreatic_hormone". A list of authors is available in Wikipedia.|