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Phenyltoloxamine



Phenyltoloxamine
Systematic (IUPAC) name
N,N-dimethyl-2-(α-phenyl-O-tolyloxy)ethylamine
Identifiers
CAS number 92-12-6
ATC code  ?
PubChem 7077
Chemical data
Formula C17H21NO 
Mol. mass 255.359
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

OTC(US)

Routes oral

Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is a member of the ethanolamine class of antihistaminergic agents and a potent anticholinergic.

Additional recommended knowledge

Common use

Phenyltoloxamine is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine.

It also used to discourage abuse in certain opiate analgesics due its unpleasant side effects at high doses.

Adverse effects

Common adverse effects are those associated with most anticholinergics, effects are more pronounced in children and the elderly.

See also: anticholinergic

Availability

Phenyltoloxamine is available in most countries, though is rare in several western countries it remains widely used around the world, particularly in the developing world.

It is not a controlled substance; however some preparations contain opiates such as codeine or hydrocodone and are controlled, when used in preparations with acetaminophen is generally over the counter.

Phenyltoloxamine is sold under wide variety of preparations, brand names and dosages around the world:

  • Ed-Flex, Dologesic, Flextra-650, Novagesic, Phenylgesic - North America
  • Codipront - Europe/South America
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Phenyltoloxamine". A list of authors is available in Wikipedia.
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