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Systematic (IUPAC) name
CAS number 86-22-6
ATC code R06AB01
PubChem 6834
DrugBank APRD00832
Chemical data
Formula C16H19BrN2 
Mol. mass 319.24
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life  ?
Excretion Urine
Therapeutic considerations
Pregnancy cat.


Legal status

Unscheduled, OTC

Routes Oral

Brompheniramine (also known as Bromfed®, Bromfenex®, and Dimetane®) is an antihistamine drug of the propylamine class. It is commonly available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.


Brompheniramine works by acting as an antagonist of histamine H1 receptors. It also functions as a moderately effective anticholinergic agent, and is likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine.

Brompheniramine is metabolised via cytochrome P450 oxidase.

Side effects

Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Brompheniramine". A list of authors is available in Wikipedia.
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