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Ketotifen



Ketotifen
Systematic (IUPAC) name
4,9-dihydro-4-(1-methyl-4-piperidinylidene)- 10H-benzocyclohepta[1,2-b]thiopen-10-one
Identifiers
CAS number 34580-14-8
ATC code R06AX17 S01GX08
PubChem 3827
DrugBank APRD01061
Chemical data
Formula C19H19NOS 
Mol. mass 309.426 g/mol
Pharmacokinetic data
Bioavailability 60%
Protein binding 75%
Metabolism Hepatic
Half life 21 Hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Oral, Eye Drops

Ketotifen fumarate (ophthalmic solutions marketed under the brand name Zaditor (Novartis) and Alaway (Bausch and Lomb)) is an H1-antihistamine/mast cell stabilizer available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. In its oral form, it is used to prevent asthma attacks. Side effects include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds.

Additional recommended knowledge

General Information

Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under 3.

Overdosage

Accidental ingestion of an entire bottle of ketotifen is unlikely to cause side effects since it contains less than 2 mg of medicine.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ketotifen". A list of authors is available in Wikipedia.
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