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Carbinoxamine



Carbinoxamine
Systematic (IUPAC) name
2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N-
dimethyl-ethanamine
Identifiers
CAS number 486-16-8
ATC code R06AA08
PubChem 2564
DrugBank APRD00765
Chemical data
Formula C16H19ClN2O 
Mol. mass 290.788 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 10 to 20 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C

Legal status

4 mg is FDA approved

Routes Oral: 4 mg tablet or 4 mg/5 mL liquid

Carbinoxamine is an H1 class antihistamine. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid. It is FDA approved (specifically at the 4 mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild urticaria; angioedema, dermatographism and allergic conjunctivitis.

Additional recommended knowledge

Carbinoxamine liquid is popular with children because the taste is very mild and easily swallowed. Palgic liquid is clear and has a bubble gum flavor.

In June, 2006 the FDA announced that more than 120 branded pharmacy products containing carbinoxamine were being illegally marketed, and demanded they be removed from the marketplace. This action was precipitated by twenty-one reported deaths in children under the age of two who had been administered carbinoxamine-containing products. Despite the fact that the drug had not been studied in this age group, a multitude of OTC preparations containing carbinoxamine were being marketed for infants and toddlers. At present, all carbinoxamine-containing formulations are approved only for adults or children ages 3 or older. [1]

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Carbinoxamine". A list of authors is available in Wikipedia.
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