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Triprolidine



Triprolidine
Systematic (IUPAC) name
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
prop-1-enyl]pyridine
Identifiers
CAS number 486-12-4
ATC code R06AX07
PubChem 5282443
DrugBank APRD00306
Chemical data
Formula C19H22N2 
Mol. mass 278.391 g/mol
SMILES search in eMolecules, PubChem
Physical data
Melt. point 60 °C (140 °F)
Solubility in water 500 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability 4% oral
Protein binding 90%
Metabolism Hepatic (CYP2D6)
Half life 4 to 6 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C (US)

Legal status

OTC (US)

Routes Oral

Triprolidine hydrochloride is an over-the-counter antihistamine. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. Like many over-the-counter antihistamines, the most common side effect is drowsiness.

Additional recommended knowledge

Trade names

Note: in some countries (Belgium e.g.), ACTIFED contains pseudoephedrine and triprolidine, but the same pharmaceutical company (GSK) has introduced an "ACTIFED New" which contains dextromethorphan hydrobromide, an anti-tussive compound unrelated to pseudoephedrine and triprolidine, and with different indications (symptomatic treatment of non-productive, irritative cough).

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Triprolidine". A list of authors is available in Wikipedia.
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