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Cyclizine is an antihistamine drug used to treat nausea, vomiting and dizziness associated with motion sickness, vertigo and post-operative following administration of general anaesthesia and opioids.
Additional recommended knowledge
Cyclizine is a piperazine derivative with histamine H1-receptor antagonist (antihistamine) activity. The precise mechanism of action in inhibiting the symptoms of motion sickness is not well understood. It may have effects directly on the labyrinthine apparatus and on the chemoreceptor trigger zone. Cyclizine exerts a central anticholinergic (antimuscarinic) action.
Its antimuscarinic action warrants caution in patients with prostatic hypertrophy, urinary retention, glaucoma. Liver disease exacerbates its sedative effects. It cannot be combined with diclofenac, for example in the same syringe or bag of fluids, as a crystallisation reaction occurs.
Common (>10%) - Drowsiness, xerostomia (dry mouth)
Uncommon (1% to 10%) - Headache, psychomotor impairment, and antimuscarinic effects such as urinary retention, diplopia (blurred vision), dermatitis, and gastro-intestinal disturbances.
Rare - Hypersensitivity reactions (bronchospasm, angioedema, anaphylaxis, rashes and photosensitivity reactions), extrapyramidal effects, dizziness, confusion, depression, sleep disturbances, tremor, liver dysfunction.
As cyclizine hydrochloride 50mg tablets and cyclizine lactate solution for intramuscular or intravenous injection (Brand names: Valoid® in UK and Marezine®, Marzine® and Emoquil® in US)).
In the UK the drug was removed from the shelves as an OTC preparation in the mid 80s because of it's interaction with opiates. It served to increase the 'flash' of injected opiates. Since opiate users would regularly use high doses, the number of ER room admissions due to seizures became a notable public health risk. Even so, the drug remains available on the internet and pockets of abuse still exist in the UK.
Lexi-Online drug database http://online.lexi.com/crlsql/servlet/crlonline
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cyclizine". A list of authors is available in Wikipedia.