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N-Ethyl-3-piperidyl benzilate



N-Ethyl-3-piperidyl benzilate
Systematic (IUPAC) name
(1-ethylpiperidin-3-yl) 2-hydroxy-2,2-di(phenyl)acetate
Identifiers
CAS number 3567-12-2
ATC code  ?
PubChem 62504
Chemical data
Formula C20H23NO3 
Mol. mass 339.43 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule I(US)

Routes  ?

N-ethyl-3-piperidyl benzilate (JB-318) is an anticholinergic drug related to the chemical warfare agent 3-Quinuclidinyl benzilate.

Additional recommended knowledge

N-ethyl-3-piperidyl benzilate is less potent and shorter acting than 3-quinuclidyl benzilate, but like 3-QNB its effects on the central nervous system predominate over peripheral effects. It produces deliriant and hallucinogenic effects similar to those of plants such as datura and may be abused recreationally at low doses, however unpleasant side effects such as dysphoria, nausea and vomiting, dizziness and extreme dry mouth tend to make abuse of these kind of drugs uncommon. Both the N-methyl and N-ethyl analogues of 3-piperidyl benzilate are however Schedule I controlled drugs.

Radiolabelled versions of this drug have been used in scientific research to map the distribution of muscarinic acetylcholine receptors in the brain, however this drug has slightly lower binding affinity than the N-methyl analogue and so is less potent and not so widely used for this application.[1]



See also


References

  1. ^ Nishiyama S, Tsukada H, Sato K, Kakiuchi T, Ohba H, Harada N, Takahashi K. Evaluation of PET ligands (+)N-[(11)C]ethyl-3-piperidyl benzilate and (+)N-[(11)C]propyl-3-piperidyl benzilate for muscarinic cholinergic receptors: a PET study with microdialysis in comparison with (+)N-[(11)C]methyl-3-piperidyl benzilate in the conscious monkey brain. Synapse. 2001 Jun 1;40(3):159-69.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "N-Ethyl-3-piperidyl_benzilate". A list of authors is available in Wikipedia.
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