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Systematic (IUPAC) name
1-[(4-chlorophenyl)- phenyl-methyl]-4- [(3-methylphenyl)methyl]piperazine
CAS number 569-65-3
ATC code A04AB04 R06AE05
PubChem 4034
DrugBank APRD00354
Chemical data
Formula C25H27ClN2 
Mol. mass 390.948 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 6 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes Oral

Meclizine (proposed INN is meclozine) is an antihistamine considered to be an antiemetic. It is most commonly used to inhibit nausea and vomiting. An alternative to dimenhydrinate (Dramamine), meclizine is considered to be equally effective, but with reduced side effects.



Motion sickness

Meclizine is effective in inhibiting the symptoms of motion sickness, such as nausea, vomiting, and dizziness.


Meclizine may be effective in relieving vertigo experienced as a result of inner ear infections or other conditions.

Risks of use


Drowsiness may result as a side effect of taking meclizine. While the effects are less than dimenhydrinate, users are advised not to operate heavy machinery while under the influence. The consumption of alcohol while under the influence of meclizine may result in additional drowsiness.


Meclizine is classified as Pregnancy Category B by the FDA.

Category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Studies have shown that cleft palates of fetuses were formed when pregnant rats were exposed to 25-50 times a normal dosage. Thus, pregnant women are advised not to take meclizine unless it is absolutely necessary.


Due to its possible anticholinergic action, meclizine should be used carefully with patients who suffer from asthma, glaucoma, or an enlarged prostate gland.

Commercial names

Meclizine hydrochloride is sold under the commercial names

  • Dramamine II®
  • Dramamine Less Drowsy®
  • Motion Sickness 2 (Longs drugstore brand)
  • Antivert®
  • Bonine®
  • Bonamine®
  • Bonikraft®
  • Emetostop®
  • Medivert®
  • Sea-Legs®
  • Agyrax®
  • Postafen® (Sweden)
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Meclizine". A list of authors is available in Wikipedia.
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