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Phosphite ester



 

Additional recommended knowledge

A phosphite ester or organophosphite is a type of chemical compound with the general structure P(OR)3. Phosphite esters can be considered as esters of phosphorous acid, H3PO3. A simple phosphite ester is trimethylphosphite, P(OCH3)3. Phosphite esters can be prepared by reacting phosphorus trichloride or phosphorus tribromide with an alcohol and a tertiary amine.

Phosphite esters are used in the Perkow reaction in the formation of vinyl phosphonates and in the Michaelis-Arbuzov reaction to form phosphonates. One other particular use is that of reducing agent. For example triethylphosphite is known to reduce certain hydroperoxides to alcohols formed by autoxidation[1] (scheme 1). In this process the phosphite is converted to a phosphate ester.

This reaction type is also utilized in the Wender Taxol total synthesis.

The compound trimethylolpropane phosphite is a ligand used in organometallic chemistry.

See also

References

  1. ^ J. N. Gardner, F. E. Carlon and O. Gnoj (1968). "One-step procedure for the preparation of tertiary α-ketols from the corresponding ketones". J. Org. Chem. 33 (8): 3294-3297. doi:10.1021/jo01272a055.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Phosphite_ester". A list of authors is available in Wikipedia.
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