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Polyketide



Polyketides are secondary metabolites from bacteria, fungi, plants, and animals. As typical for secondary metabolites, polyketides are dispensable for normal growth of the organism producing it, but may inhibit growth of other organisms or have roles as compounds involved in biological signalling. Polyketides are synthesized in vivo by the polymerization of acetyl and propionyl subunits in a similar process to fatty acid synthesis. [1] They are the building blocks for a broad range of natural products or are further derivatized.

Polyketides are structurally a very diverse family of natural products with an extremely broad range of biological activities and pharmacological properties. Polyketide antibiotics, antifungals, cytostatics, anticholesterolemics, antiparasitics, coccidiostatics, animal growth promoters and natural insecticides are in commercial use.[citation needed]

Additional recommended knowledge

Contents

Examples

Biosynthesis

Polyketides are synthesized by one or more specialized and highly complex polyketide synthase (PKS) enzymes. [1]

References

  1. ^ a b Robinson JA (1991). "Polyketide synthase complexes: their structure and function in antibiotic biosynthesis". Philos Trans R Soc Lond B Biol Sci. 332: 107-114. PMID 1678529.

See also

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Polyketide". A list of authors is available in Wikipedia.
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