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Pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) is a terpenoid acid present at micromolar concentrations in the blood plasma of healthy individuals. It is also found in the lipids from many sources such as freshwater sponges, krill, earthworms, whales, human milk fat, bovine depot fat, butterfat or Californian petroleum. It is usually present in combination with phytanic acid. In humans, pristanic acid is obtained from two sources: either directly from the diet or as the alpha oxidation product of phytanic acid. At physiological concentrations pristanic acid is a natural ligand for PPARα. In liver, pristanic acid is degraded by peroxisomal beta oxidation to propionyl-CoA. Together with phytanic acid, pristanic acid accumulates in several inherited disorders such as Zellweger syndrome.
Additional recommended knowledge
Pristanic acid was first isolated from butterfat by R. P. Hansen and J. D. Morrison in 1964hydrocarbon. Pristane was isolated from shark liver and was named after Latin pristis, "shark".. The name of the substance is derived from pristane (2,6,10,14-tetramethylpentadecane), the corresponding
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pristanic_acid". A list of authors is available in Wikipedia.|