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Protein Z-related protease inhibitor
Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.
Additional recommended knowledge
Role in disease
Water et al found deficiency of ZPI in 4.4% of a cohort of patients with thrombophilia (a tendency to thrombosis).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Protein_Z-related_protease_inhibitor". A list of authors is available in Wikipedia.|