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Quinupristin/dalfopristin (Synercid®) is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections.
Quinupristin and dalfopristin are both streptogramin antibiotics, derived from pristinamycin. Quinupristin is derived from pristinamycin I; dalfopristin from pristinamycin IIA. They are combined in a weight-to-weight ratio of 30% quinupristin to 70% dalfopristin.
Additional recommended knowledge
Intravenous, usually 7.5 mg/kg every 8-12 hours
Mechanism of action
Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. The combination of the two components acts synergistically and is more effective in vitro than each component alone.
Clearance by the liver, half-life 1-3 hours (with persistence of effects for 9-10 hours).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Quinupristin/dalfopristin". A list of authors is available in Wikipedia.|