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RANK



tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Identifiers
Symbol TNFRSF11A
Entrez 8792
HUGO 11908
OMIM 603499
RefSeq NM_003839
UniProt Q9Y6Q6
Other data
Locus Chr. 18 q22.1

RANK (Receptor Activator of Nuclear Factor κ B), also known as TRANCE Receptor, is a type I membrane protein which is expressed on the surface of osteoclasts and is involved in the activation of osteoclasts upon ligand binding. It is also expressed on dendritic cells and facilitates immune signaling. RANK ligand is found on the surface of stromal cells, osteoblasts, and T cells.

Additional recommended knowledge

See also

  • Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L and RANK: T cells, bone loss, and mammalian evolution". Annu. Rev. Immunol. 20: 795-823. doi:10.1146/annurev.immunol.20.100301.064753. PMID 11861618.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "RANK". A list of authors is available in Wikipedia.
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