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tumor necrosis factor receptor superfamily, member 9
Symbol TNFRSF9
Alt. Symbols CD137, 4-1BB, ILA
Entrez 3604
HUGO 11924
OMIM 602250
RefSeq NM_001561
UniProt Q07011
Other data
Locus Chr. 1 p36

CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA).



CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

Specific effects on cells

The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

See also

  • 4-1BB ligand


  • Kwon BS, Weissman SM (1989). "cDNA sequences of two inducible T-cell genes". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1963-7. PMID 2784565.
  • Schwarz H, Tuckwell J, Lotz M (1993). "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family". Gene 134 (2): 295-8. PMID 8262389.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD137". A list of authors is available in Wikipedia.
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