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CD29




Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Identifiers
Symbol(s) ITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLAB
External IDs OMIM: 135630 MGI: 96610 Homologene: 22999
RNA expression pattern

Additional recommended knowledge

More reference expression data

Orthologs
Human Mouse
Entrez 3688 16412
Ensembl ENSG00000150093 ENSMUSG00000025809
Uniprot P05556 Q3TIW5
Refseq NM_002211 (mRNA)
NP_002202 (protein)
NM_010578 (mRNA)
NP_034708 (protein)
Location Chr 10: 33.23 - 33.29 Mb Chr 8: 131.59 - 131.62 Mb
Pubmed search [1] [2]

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), also known as ITGB1 or CD29, is a human gene. CD29 is an integrin unit associated with very late antigen receptors.


Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.[1]


References

  1. ^ Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12).

Further reading

  • Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization.". Bioessays 23 (7): 628-39. doi:10.1002/bies.1088. PMID 11462216.
  • Armulik A (2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions.". Front. Biosci. 7: d219-27. PMID 11779688.
  • Brakebusch C, Fässler R (2006). "beta 1 integrin function in vivo: adhesion, migration and more.". Cancer Metastasis Rev. 24 (3): 403-11. doi:10.1007/s10555-005-5132-5. PMID 16258728.



 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD29". A list of authors is available in Wikipedia.
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