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CD18




Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
PDB rendering based on 1l3y.
Available structures: 1l3y, 1yuk
Identifiers
Symbol(s) ITGB2; LAD; LFA-1; MAC-1; CD18; LCAMB; MF17; MFI7
External IDs OMIM: 600065 MGI: 96611 Homologene: 20092
RNA expression pattern

Additional recommended knowledge

More reference expression data

Orthologs
Human Mouse
Entrez 3689 16414
Ensembl ENSG00000160255 ENSMUSG00000000290
Uniprot P05107 Q542I8
Refseq NM_000211 (mRNA)
NP_000202 (protein)
NM_008404 (mRNA)
NP_032430 (protein)
Location Chr 21: 45.13 - 45.17 Mb Chr 10: 76.99 - 77.01 Mb
Pubmed search [1] [2]

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), also known as CD18 or ITGB2, is a human gene.

CD18 is the beta subunit of three different structures:

  • LFA-1 (paired with CD11a)
  • Macrophage-1 antigen (paired with CD11b)
  • Integrin alphaXbeta2 (paired with CD11c)


The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.[1]


References

  1. ^ Entrez Gene: ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit).

Further reading

  • Bunting M, Harris ES, McIntyre TM, et al. (2002). "Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands.". Curr. Opin. Hematol. 9 (1): 30-5. PMID 11753075.
  • Roos D, Law SK (2003). "Hematologically important mutations: leukocyte adhesion deficiency.". Blood Cells Mol. Dis. 27 (6): 1000-4. doi:10.1006/bcmd.2001.0473. PMID 11831866.
  • Gahmberg CG, Fagerholm S (2003). "Activation of leukocyte beta2-integrins.". Vox Sang. 83 Suppl 1: 355-8. PMID 12617168.
  • Schymeinsky J, Mócsai A, Walzog B (2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications.". Thromb. Haemost. 98 (2): 262-73. PMID 17721605.

See also

  • leukocyte adhesion deficiency
  • integrin


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD18". A list of authors is available in Wikipedia.
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