My watch list
my.chemeurope.com  
Login  

CD23



CD23
Identifiers
Symbol FCER2
Alt. Symbols CD23A, FCE2
Entrez 2208
HUGO 3612
OMIM 151445
RefSeq NM_002002
UniProt P06734
Other data
Locus Chr. 19 p13.3

CD23, also known as Fc epsilon RII, or FcεRII, is the "low affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells and platelets.

Additional recommended knowledge

There are two forms of CD23: CD23a and CD23b. CD23a is unconditionally present on B cells, while CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils and macrophages.[1]

The allergen responsible in dust mite allergy, Der-p-1, is known to cleave CD23 from a cells surface. As CD23 is soluble it can move freely and interact with cells in plasma. Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen specific B-cells, therefore increasing the production of allergen specific IgE. IgE in turn is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high affinity IgE receptor).

References

  1. ^ Abbas, A.K. and Andrew Licktman, 2003, Cellular and Molecular Immunology, pp.324-325. ISBN 0-7216-0008-5.

See also


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD23". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE