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FcεRI



Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Identifiers
Symbol FCER1A
Alt. Symbols FCE1A
Entrez 2205
HUGO 3609
OMIM 147140
RefSeq NM_002001
UniProt P12319
Other data
Locus Chr. 1 q23
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
Identifiers
Symbol MS4A2
Alt. Symbols FCER1B, IGER, APY
Entrez 2206
HUGO 7316
OMIM 147138
RefSeq NM_000139
UniProt Q01362
Other data
Locus Chr. 1 q23
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Identifiers
Symbol FCER1G
Entrez 2207
HUGO 3611
OMIM 147139
RefSeq NM_004106
UniProt P30273
Other data
Locus Chr. 1 q23

FcεRI, or Fc epsilon RI, is the high-affinity receptor for immunoglobulin E (IgE), an antibody isotype involved in allergy and resistance to parasites. FcεRI is a tetrameric receptor complex consisting of one alpha (FcεRIα), one beta (FcεRIβ), and two gamma chains (FcεRIγ). It is expressed predominantly on mast cells and basophils.

Additional recommended knowledge

Crosslinking of the FcεRI via IgE-allergen complexes leads to degranulation of mast cells or basophils and release of inflammatory mediators. At laboratory conditions degranulation of isolated basophils can also be induced with antibodies to the FcεRIα which crosslink the receptor. Such crosslinking and potentially pathogenic autoantibodies to the FcεRIα have been isolated from human cord blood, which suggest that they occur naturally and are present already at birth. However, their epitope on FcεRIα was masked by IgE and the affinity of the corresponding autoantibodies found in healthy adults appeared lowered.[1]

References

  1. ^ The Journal of Immunology 2005, 175: 6589-6596. (Bobrzynski et al., 2005, PMID: 16272313, Full text)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "FcεRI". A list of authors is available in Wikipedia.
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