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Integrin alpha4beta1 ( Very Late Antigen-4) is an integrin dimer. It is composed of CD49d (alpha) and CD29 (beta).
Additional recommended knowledge
[VCAM-1] (integrin receptor) binds to the integrin
VLA-4 which are normally expressed on leukocyte plasma membranes, but they do not adhere to their appropriate ligands until the leukocytes are activated by chemotactic agents or other stimuli (often produced by the endothelium or other cells at the site of injury). Only then do the integrins undergo the conformational change necessary to confer high binding affinity for the endothelial adhesion molecules.
Transmembrane receptors: immune receptors Cytokine receptor Type I: ( interleukin IL-2, IL-3) - CSF (Erythropoietin, GM-CSF, G-CSF) - Glycoprotein 130/Oncostatin M - Leukemia inhibitory factor - common subunits (Common gamma chain, CSF2RB)
Type II: (IL22RA2) - interleukin interferon (IFNAR, IFNGR)
Chemokine - TGF-beta - Tumor necrosis factor Pattern recognition/ Toll-like TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 Fc receptor ε ( FcεRI, FcεRII) - γ ( FcγRI, FcγRII, FcγRIII) - α/μ ( FcαRI, Fcα/μR) - Neonatal Lymphocyte homing receptor CD44 - L-selectin - VLA-4 - LFA-1 other Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger
This article is licensed under the
GNU Free Documentation License. It uses material from the Wikipedia article "VLA-4". A list of authors is available in Wikipedia.
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