My watch list
my.chemeurope.com  
Login  

Type I cytokine receptor



Type I cytokine receptors are proteins expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

Additional recommended knowledge

Families

The signal transducing chains are often shared between different receptors within this receptor family.[1]

  • The IL-2 receptor common gamma chain (also known as CD132) is shared between IL-2, IL-4, IL-7, IL-9, IL-13 and IL-15 receptors[2]
  • The common beta chain (CD131 or CDw131) is shared between GM-CSF, IL-3 and IL-5.[3]

Examples

Type I cytokine receptors include:

References

  1. ^ Abbas AK, and Lichtman, Cellular and Molecular Immunology (5th Ed.) Editor: Saunders, Philadelphia, 2003.
  2. ^ He et al., Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. J Immunol. 1995 Feb 15;154(4):1596-605
  3. ^ Woodcock et al., Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 1994 November 1; 13(21): 5176–5185.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Type_I_cytokine_receptor". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE