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E-selectin




Selectin E (endothelial adhesion molecule 1)
PDB rendering based on 1esl.
Available structures: 1esl, 1g1t
Identifiers
Symbol(s) SELE; CD62E; ELAM; ELAM1; ESEL; LECAM2
External IDs OMIM: 131210 MGI: 98278 Homologene: 389
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 6401 20339
Ensembl ENSG00000007908 ENSMUSG00000026582
Uniprot P16581 Q3U5F6
Refseq NM_000450 (mRNA)
NP_000441 (protein)
NM_011345 (mRNA)
NP_035475 (protein)
Location Chr 1: 167.96 - 167.97 Mb Chr 1: 165.88 - 165.89 Mb
Pubmed search [1] [2]

E-selectin, also known as CD62E, is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation.

Additional recommended knowledge

Contents

Ligands

E-selectin recognises and binds to sialylated carbohydrates present on the surface proteins of certain leukocytes. These carbohydrates include members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes[1].

Function

During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF by damaged cells induces the expression of E-selectin on endothelial cells of nearby blood vessels[1]. Leukocytes in the blood expressing the correct ligand will bind with low affinity to E-selectin, causing the leukocytes to "roll" along the internal surface of the blood vessel as temporary interactions are made and broken.

As the inflammatory response progresses, chemokines released by injured tissue enter the blood vessels and activate the rolling leukocytes, which are now able to tightly bind to the endothelial surface and begin making their way into the tissue[1].

P-selectin has a similar function, but is expressed on the endothelial cell surface within minutes as it is stored within the cell rather than produced on demand[1].

References

  1. ^ a b c d Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. 0-7216-7335-X. 

Further reading

  • Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms.". Curr. Opin. Immunol. 4 (1): 33-7. PMID 1375831.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "E-selectin". A list of authors is available in Wikipedia.
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