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CD49a




Integrin, alpha 1
PDB rendering based on 1ck4.
Available structures: 1ck4, 1mhp, 1pt6, 1qc5, 1qcy, 2b2x
Identifiers
Symbol(s) ITGA1; CD49a; VLA1
External IDs OMIM: 192968 MGI: 96599 Homologene: 57137
Orthologs
Human Mouse
Entrez 3672 109700
Ensembl na ENSMUSG00000042284
Uniprot na Q05DI0
Refseq NM_181501 (mRNA)
NP_852478 (protein)
NM_001033228 (mRNA)
NP_001028400 (protein)
Location na Chr 13: 116.08 - 116.22 Mb
Pubmed search [1] [2]

Additional recommended knowledge

CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.


This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[1]


References

  1. ^ Entrez Gene: ITGA1 integrin, alpha 1.

Further reading

  • Virtanen I, Korhonen M, Kariniemi AL, et al. (1991). "Integrins in human cells and tumors.". Cell Differ. Dev. 32 (3): 215-27. PMID 2099238.
  • Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis.". Atherosclerosis 166 (1): 1-11. PMID 12482545.
  • Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture.". J. Cell. Sci. 103 ( Pt 1): 267-71. PMID 1429908.
  • Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.". J. Biol. Chem. 265 (11): 5938-41. PMID 1690718.
  • Sonnenberg A, Linders CJ, Modderman PW, et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.". J. Cell Biol. 110 (6): 2145-55. PMID 1693624.
  • Belkin VM, Belkin AM, Dol'nikova AE, et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia 56 (12): 2198-206. PMID 1807406.
  • Bank I, Roth D, Book M, et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases.". J. Clin. Immunol. 11 (1): 29-38. PMID 1827128.
  • Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium.". J. Clin. Endocrinol. Metab. 71 (3): 645-9. PMID 2144294.
  • Tawil NJ, Houde M, Blacher R, et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells.". Biochemistry 29 (27): 6540-4. PMID 2169872.
  • Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development.". J. Cell Biol. 111 (5 Pt 1): 2159-70. PMID 2229189.
  • MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine.". J. Clin. Pathol. 43 (4): 313-5. PMID 2341567.
  • Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239-43. PMID 3033641.
  • Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.". J. Biol. Chem. 262 (7): 3300-9. PMID 3546305.
  • Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system.". Exp. Cell Res. 221 (2): 478-85. doi:10.1006/excr.1995.1399. PMID 7493648.
  • Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk.". Immunol. Cell Biol. 72 (4): 306-13. PMID 7806264.
  • Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees.". J. Histochem. Cytochem. 43 (4): 447-57. PMID 7897185.
  • Pfaff M, Aumailley M, Specks U, et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI.". Exp. Cell Res. 206 (1): 167-76. doi:10.1006/excr.1993.1134. PMID 8387021.
  • Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit.". J. Biol. Chem. 268 (4): 2989-96. PMID 8428973.
  • Langholz O, Röckel D, Mauch C, et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins.". J. Cell Biol. 131 (6 Pt 2): 1903-15. PMID 8557756.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD49a". A list of authors is available in Wikipedia.
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