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CD46




CD46 molecule, complement regulatory protein
PDB rendering based on 1ckl.
Available structures: 1ckl, 2o39
Identifiers
Symbol(s) CD46; MCP; MGC26544; MIC10; TLX; TRA2.10
External IDs OMIM: 120920 MGI: 1203290 Homologene: 7832
RNA expression pattern

Additional recommended knowledge

More reference expression data

Orthologs
Human Mouse
Entrez 4179 17221
Ensembl ENSG00000117335 ENSMUSG00000016493
Uniprot P15529 O88174
Refseq NM_002389 (mRNA)
NP_002380 (protein)
NM_010778 (mRNA)
NP_034908 (protein)
Location Chr 1: 205.99 - 206.04 Mb Chr 1: 196.76 - 196.79 Mb
Pubmed search [1] [2]

CD46 is an inhibitory complement receptor.

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.[1]

References

  1. ^ Entrez Gene: CD46 CD46 molecule, complement regulatory protein.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD46". A list of authors is available in Wikipedia.
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