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CD49b




Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
PDB rendering based on 1aox.
Available structures: 1aox, 1dzi, 1v7p
Identifiers
Symbol(s) ITGA2; BR; CD49B; GPIa; VLA-2; VLAA2
External IDs OMIM: 192974 MGI: 96600 Homologene: 1662
Orthologs
Human Mouse
Entrez 3673 16398
Ensembl ENSG00000164171 ENSMUSG00000015533
Uniprot P17301 Q6P1C7
Refseq NM_002203 (mRNA)
NP_002194 (protein)
XM_982915 (mRNA)
XP_988009 (protein)
Location Chr 5: 52.32 - 52.42 Mb Chr 13: 115.96 - 116.05 Mb
Pubmed search [1] [2]

Additional recommended knowledge

CD49b is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex.


This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.[1]


References

  1. ^ Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor).

Further reading

  • Moroi M, Jung SM (1997). "Platelet receptors for collagen.". Thromb. Haemost. 78 (1): 439-44. PMID 9198193.
  • Takada Y, Kamata T, Irie A, et al. (1998). "Structural basis of integrin-mediated signal transduction.". Matrix Biol. 16 (4): 143-51. PMID 9402003.
  • Dickeson SK, Santoro SA (1998). "Ligand recognition by the I domain-containing integrins.". Cell. Mol. Life Sci. 54 (6): 556-66. PMID 9676575.
  • Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390-6. PMID 9789327.
  • Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis.". Atherosclerosis 166 (1): 1-11. PMID 12482545.
  • Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.". Italian heart journal : official journal of the Italian Federation of Cardiology 4 (1): 17-22. PMID 12690916.
  • Tsantes AE, Nikolopoulos GK, Bagos PG, et al. (2007). "Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis.". Int. J. Cardiol. 118 (2): 189-96. doi:10.1016/j.ijcard.2006.06.047. PMID 17023078.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD49b". A list of authors is available in Wikipedia.
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