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Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Symbol(s) ITGA3; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a
External IDs OMIM: 605025 MGI: 96602 Homologene: 21129
RNA expression pattern

More reference expression data

Human Mouse
Entrez 3675 16400
Ensembl ENSG00000005884 ENSMUSG00000001507
Uniprot P26006 Q5SWB9
Refseq NM_002204 (mRNA)
NP_002195 (protein)
NM_013565 (mRNA)
NP_038593 (protein)
Location Chr 17: 45.49 - 45.52 Mb Chr 11: 94.86 - 94.89 Mb
Pubmed search [1] [2]

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor), also known as ITGA3 and CD49c, is a human gene. ITGA3 is an integrin alpha subunit. It makes up half of the α3β1 integrin duplex.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').[1]


  1. ^ Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor).

Further reading

  • Bosman FT (1993). "Integrins: cell adhesives and modulators of cell function.". Histochem. J. 25 (7): 469-77. PMID 8407358.
  • Fornaro M, Languino LR (1998). "Alternatively spliced variants: a new view of the integrin cytoplasmic domain.". Matrix Biol. 16 (4): 185-93. PMID 9402008.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD49c". A list of authors is available in Wikipedia.
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