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RS 67333

RS 67333
Systematic name 1-(4-Amino-5-chloro-2-methoxyphenyl)-


Chemical formula C19H29N2O2Cl
Molecular weight 352.9 g/mol
CAS number [160845-95-4]
SMILES C(CCC1CCN(CC1)CCCC)(=O)c1c(cc(c(c1)Cl)N)OC
Disclaimer and references

RS 67333 is a 5-HT4 receptor partial agonist, being researched as a possible rapid acting antidepressant [1], nootropic [2], and treatment for Alzheimer's [3].


  1. ^ Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. (2007). "Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action.". Neuron. 55 (5): 712–25. PMID 17785179.
  2. ^ Lamirault L, Simon H. (2001). "Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors.". Neuropharmacology. 41 (7): 844–53. PMID 11684148.
  3. ^ Cho S, Hu Y. (2007). "Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.". Experimental Neurology. 203 (1): 274–8. PMID 16978609.
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