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Retinol binding protein 4

Human serum retinol binding protein. From PDB 1RBP.
retinol binding protein, plasma
Symbol RBP4
Entrez 5950
HUGO 9922
OMIM 180250
RefSeq NM_006744
UniProt P02753
Other data
Locus Chr. 10 q24

Retinol binding protein (RBP coded by the gene RBP4) has recently been described as an adipokine that contributes to insulin resistance in the AG4KO mouse model.[1]

It is secreted by adipocytes, and can act as a signal to other cells, when there is a decrease in plasma glucose concentration.[2]

See also


  1. ^ Yang, Q. et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436:35-362
  2. ^ Herman, M.A and Kahn, B.B. (2006) Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. The Journal of Clincial Investigation. 116:1767-1775 link
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Retinol_binding_protein_4". A list of authors is available in Wikipedia.
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