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Additional recommended knowledge
The protic acid is often an impurity in the Lewis Acid and also formed in the course of a Scholl reaction. Reagents are iron(III) chloride in dichloromethane, copper(II) chloride, PIFA and boron trifluoride etherate in dichloromethane, Molybdenum(V) chloride and lead tetraacetate with BF3 in acetonitrile .
Given the high reaction temperature and the requirement for strongly acidic catalysts the chemical yield often are low and the method is not a popular one. Intramolecular reactions fair better than the intermolecular ones, for instance in the organic synthesis of 9-phenylfluorene:
The exact reaction mechanism is not known but could very well proceed through an arenium ion. Just as in electrophilic aromatic substitution, Activating groups such as methoxy improve yield and selectivity :
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Scholl_reaction". A list of authors is available in Wikipedia.|