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Soluble low density lipoprotein receptor-related protein



Soluble low density lipoprotein receptor-related protein (sLRP) is a biological substance naturally produced by the human body.[1][2] This protein has been found to bind to and neutralize anywhere from 70 to 90 percent of the amyloid-beta peptide that also naturally circulates in healthy human or mouse plasma.[3] Impairment of this function is strongly associated with, and may soon be shown definitively to be the principal cause of, Alzheimer's Disease.[4]

References

  1. ^ Quinn KA, Pye VJ. et al. (1999). "Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP)". Exp. Cell Res. 251 (2): 433-441. PMID 10471328.
  2. ^ Quinn KA, Grimsley PG, et al. (1997). "Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma". J. Biol. Chem. 272 (38): 23946-23951. PMID 9295345.
  3. ^ Draining away brain's toxic protein to stop Alzheimer's. Retrieved on 2007-10-25.
  4. ^ Sagare A, Deane R. et al. (2007). "Clearance of amyloid-beta by circulating lipoprotein receptors.". Nat. Med. 13 (9): 1029-1031. PMID 17694066.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Soluble_low_density_lipoprotein_receptor-related_protein". A list of authors is available in Wikipedia.
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