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Stork enamine alkylation
Stork enamine alkylation, also known as the Stork-Enamine reaction, involves the addition of an enamine to an alpha,beta-unsaturated carbonyl acceptor in a process similar to the Michael reaction . The product is then hydrolyzed by an aqueous acid to produce a 1,5-dicarbonyl compound.
Additional recommended knowledge
The reaction is named after its inventor: Gilbert Stork.
In this method a carbonyl compound is converted to an imine by alkylimino-de-oxo-bisubstitution with a primary amine. The imine is then reacted with an Grignard reagent to the corresponding magnesium salt to an intermediate capable of displacing a halide. Hydrolysis once again yields the alkylated ketone.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Stork_enamine_alkylation". A list of authors is available in Wikipedia.|