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Tenascins are extracellular matrix glycoproteins. They are abundant in the extracellular matrix of developing vertebrate embryos and they reappear around healing wounds and in the stroma of some tumors.
Additional recommended knowledge
There are four members of the tenascin gene family: tenascin-C, tenascin-R, tenascin-X and tenascin-W.
Tenascin-C is the best understood. It has anti-adhesive properties, causing cells in tissue culture to become rounded after it is added to the medium. One mechanism to explain this may come from its ability to bind to the extracellular matrix glycoprotein fibronectin and block fibronectin's interactions with specific syndecans. The expression of tenascin-C in the stroma of certain tumors is associated with a poor prognosis.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tenascin". A list of authors is available in Wikipedia.|