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Thiabendazole



Thiabendazole
Systematic (IUPAC) name
2-(1,3-thiazol-4-yl)-1H-benzoimidazole
Identifiers
CAS number 148-79-8
ATC code D01AC06 P02CA02
PubChem 5430
DrugBank APRD01252
Chemical data
Formula C10H7N3S 
Mol. mass 201.249 g/mol
SMILES search in eMolecules, PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Thiabendazole (or tiabendazole) is a fungicide and parasiticide.

Additional recommended knowledge

Thiabendazole is abbreviated to "TBZ". It is produced by Merck under the brand name Mintezol®.

Uses

It is used primarily to control mold, blight, and other fungally caused diseases in fruits (e.g. oranges) and vegetables. It is able to control roundworms, hookworms, and other helminth species which attack wild animals, livestock and humans.

Thiabendazole is applied to some bananas, including Chiquita brand bananas 'to ensure freshness'.

Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.

Thiabendazole is also used as a food additive, a preservative with E number E233.

Thiabendazole is also used to treat ear infections in dogs and cats. It is sold by Merial under the brand name Tresaderm.

The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestine distorder at high exposure in test animals (just below LD50 level). Some reproductive distorders and decreasing weanling weight have been observed, also at high exposure. Effects on humans from use as drug includes nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine. No mutagenic or carcinogenic effects have been shown.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Thiabendazole". A list of authors is available in Wikipedia.
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